Congenital Adrenal Hyperplasia Due to 21alpha-Hydroxylase Deficiency

Completing this online activity consists of five steps:

1. Read all information below
2. Read the article
3. Take the posttest
4. Complete the registration and evaluation form
5. Fill out and print your receipt of hours completed

Release Date: December 01, 2008
Valid for credit through: November 30, 2009

Jointly sponsored by the University of Minnesota and University of Minnesota Children's Hospital, Fairview.

Credits Available:
Up to 1.0 AMA PRA Category 1 CME credits

CAH is the leading cause of genital ambiguity in newborn females. If undiagnosed or not treated, patients with the severe form can go into adrenal shock and/or death. The most frequent form of CAH is due to 21α-hydroxylase deficiency (21-OHD) which is inherited in an autosomal recessive fashion.  The sequelae of CAH due to 21-OHD has its greatest impact during childhood affecting linear growth; pubertal development; and female genital development (which subsequently can lead to genital surgery and gender role issues). If treatment, which consists of replacing the hormones not produced because of the enzymatic defect, is not specifically tailored for the individual patient and carefully monitored, negative outcomes can occur because of undertreatment/non-compliance or from the steroid medications used as replacement therapy. As general pediatricians share in the care of CAH patients, it is important to more fully understand the course of the disease and the best practices in monitoring and treatment so that children with CAH may have improved outcomes.

Step One: READ ALL INFORMATION BELOW

Target Audience

This activity would be ideal for all pediatricians and primary care specialties.

Educational Objectives

After reading this article, you should be able to:

• Outline the pathyophysiology of congenital adrenal hyperplasia (CAH) due to 21α-hydroxylase deficiency (21-OHD) and distinguish between the different forms which include classical CAH (salt-wasting and simple virilizing forms) and non-classical CAH
• Elucidate the varied manifestations that affect patients with CAH from childhood through adulthood and understand the need for multidisciplinary, patient-centered, team approach in caring for these patients

Estimated Time to Complete

1 hour

Method of Participation

There are no fees to participate and receive CME credit for this activity. Participants must read the objectives and faculty disclosures, study the educational activity, complete the posttest by recording the best answer, register, and complete the evaluation. A statement of hours will then be issued on this Web site.

Accreditation

This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the University of Minnesota and the University of Minnesota Children's Hospital, Fairview. The University of Minnesota is accredited by the ACCME to provide continuing medical education for physicians.

The University of Minnesota designates this educational activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Disclosure Statements

Author

Kyriake Sarafoglou, M.D.
Director, Leo Fung Center for Congenital Adrenal Hyperplasia and Disorders of Sex Development Division of Pediatric Endocrinology Division of Genetics and Metabolism University of Minnesota.
Disclosure: Dr. Sarafoglou has nothing to disclose

Editor

Danielle Johnson
University of Minnesota Children's Hospital, Fairview
Disclosure: Danielle Johnson has nothing to disclose

Planning Committee

Rachel Anderson
University of Minnesota Children's Hospital, Fairview
Disclosure: Rachel Anderson has nothing to disclose

Disclosure Policy

It is the policy of the University of Minnesota Office of Continuing Medical Education to ensure balance, independence, objectivity and scientific rigor in all of its sponsored educational activities. All participating faculty, course directors, and planning committee members are required to disclose to the program audience any financial relationships related to the subject matter of this program. Relationships of spouse/ partner with proprietary entities producing health care goods or services should be disclosed if they are of a nature that may influence the objectivity of the individual in a position to control the content of the CME activity. Disclosure information is reviewed in advance in order to manage and resolve any possible conflicts of interest. Specific disclosure information for each course faculty will be shared with the audience prior to the faculty's presentation.

Commercial Support

There is no commercial support for this activity.

Feedback

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Step Two: READ THE ARTICLE

Step Three: TAKE THE POSTTEST (if you have already read the article)